Basic Information
The Chemistry of Macromolecules, Different Levels of Protein Structure, Mapping The Protein Universe, Principles Forces in Protein Folding, Why Is Double-stranded Dna Helical, What Came First Protein Sequence Or Structure. Designability Principle. Simulating Macromolecular Structures, Kinetics of Protein Folding. Experimental Methods For Studying Folding. Protein Engineering and Design. in Vitro Evolution of Novel Proteins From Scratch. Principles of Designig Ideal Protein Structures. Disordered Proteins and Natively Unfolded Proteins. The Role of Water in The Structure and Function Of Biomolecules. Learning Outomes# On Successful Completion of This Module, Students Should Be Able To# 1. Understand The Basic Forces That Shape Both Proteins and Nucleic Acids Structure. What Mutations Do For a Protein Structure and How to Go About Designing Them For Specific Purposes. 2. Understand What Determines Protein Folding And Stability. 3. Understand The Versatility of Natively Unfolded Proteins - What They Are Good For and Why. 4. Understand Ab Initio Rational Desig Principles of Protein Form Scratch and From Pre-existing Folds, Towards Synthetic Biology. 5. Read and Understnad Current Primary Paper Written On Protein Folding and Design, Sufficiently to Present The Subject Orally and Write a Term Paper On It.
Faculty: Biology
|Graduate Studies
Pre-required courses
(124510 - Physical Chemistry and 134113 - Metabolic Pathways) or (124510 - Physical Chemistry and 134019 - Introduction to Biochemistry and Enzymology)
Parallel course
Course with no extra credit
138093 - Structure and Function of Macromolecules
Related Books
- Introduction to protein structure / Carl Branden, John Tooze. - Branden, Carl
- Physical chemistry : principles and applications in biological sciences / Ignacio Tinoco, Jr. ...[ et al.]. - Tinoco, Ignacio
- Physical chemistry : principles and applications in biological sciences / Ignacio Tinoco, Jr., University of California, Berkeley, Kenneth Sauer, University of California, Berkeley, James C. Wang, Harvard University, Joseph D. Puglisi, Stanford University, David Rovnyak, Bucknell University. - Tinoco, Ignacio
- Principles of physical biochemistry / Kensal E. Van Holde,W. Curtis Johnson and Pui Shing Ho. - Van Holde, Kensal E.
- Principles of Protein Structure [electronic resource] - Schulz, Georg E.
- Protein physics : a course of lectures / Alexei V. Finkelstein, Oleg B. Ptitsyn, Institute of Protein Research, Russian Academy of Sciences. - Finkelstein, Alexei V.
- Proteins : structures and molecular properties / Thomas E. Creighton. - Creighton, Thomas E.
- Structure and mechanism in protein science : a guide to enzyme catalysis and protein folding - Fersht, Alan,