Multiple Codes On The Dna Double Helix With Focus On Codes For Packaging Into Nuclesomes and For Recognition By Sequence-specific Dna Binding Proteins (dbp). Protein-dna Interactions - Protein Motifs Involved in Specific Dna Recognition. Protein-dna Interactions - Direct and Indirect Readout of Dna, The Role of Dna Structure In Specific and Non-specific Interactions. Methods For Specificity And Selectivity of Interactions in Various Protein-dna Families. Is There Code For Dna Recognition By Dbp. Target Site Location By Sequence- Specific Dbp. Experimental and Computational Methods to Study Protein- Dna Interactions. Structure of The P53 Protein. Sequence-specific Binding of P53 to Its Response Elements Regulation of P53 Activity By Post-translation Modifications. P53 Is a Hub Protein. P53 As a Gene Network. The P53 Circuit Board, P53 As Tumor Suppressor - Response To Cellular Stress. Target Sit Location By P53 Oscillations and Dynamics, P53 Smart Or Dumb. Mutant P53 and Its Oncogenic Activities. Learning Outcomes# On Successful Completion of This Module, Students Should Be Able To# 1. Understand The Mechanisms Used By Dna-binding Proteins to Recognize Their Target Sites On Dna. 2. Understand Search Mechanism Used By Dna-binding Proteins to Locate Their Binding Sites On Dna. 3. Understand How Dna Sequence and Structure Is Used As A Source of Specificity in The Their Binding to Regulaotry Proteins (transcription Factors, Nucleosome and Architectural Proteins). 4. Understand What We Currenlty Know On P53 As a Transcription Factor That Binds to Multiple Sites On The Genome and Functions in Multiple Regulatory Roles. 5. Understand How The Most Importamnt Hub Protien Works *current Knowledge) and How It Decide Which Pathway to Activate Upon a Certain Stress. 6. Read The Understand a Current Primary Paper Written On Binding of a Dna Binding Protein to Dna, Or On P53/dna Interactions, Sufficiently to Present The Subject Orally and Write A Term Paper On It.

Faculty: Biology
|Graduate Studies
Pre-required courses

(134019 - Introduction to Biochemistry and Enzymology and 134082 - Molecular Biology and 134119 - Regulation of Gene Expression)

Semestrial Information

Weekly Hours

2 Academic Credit • 2 Lecture Hours

Responsible(s)

Tali Haran

No Registration Groups